Clorazepate dipotassium (Tranxene) : a controlled evaluation in alcoholic patients after withdrawal
Mielke, D.H.; Gallant, D.M.; McFarlain, R.A.
Current Therapeutic Research 19(5): 506-511
1976
ISSN/ISBN: 0011-393X PMID: 7433 Document Number: 3636
A double-blind four-week evaluation of clorazepate, diazepam and placebo was carried out in 91 non-psychotic, volunteer patients recently withdrawn from alcohol. Change scores varied with the psychometric measurement analyzed (nonparametric). A special analysis of data from matched subjects was also performed. All three groups showed significant decreases in anxiety during this study, although the most anxious subjects showed the most improvement. The positive relationship between initial anxiety and improvement was strongest for the two active medication groups on all three measures examined. The significant drug group differences obtained suggested a weak drug effect. Over-all, there is the suggestion that those subjects who are among the most severely anxious will profit the most from both anxiolytic agents.
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