The properties of the brain dopamine and GABA receptors in rats with chronic alcoholic intoxication with different ethanol withdrawal times
Vekshina, N.L.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(3): 65-67
1992
ISSN/ISBN: 0869-2092 PMID: 1333864 Document Number: 391522
Marked changes in dopamine and GABA receptors in the brain of rats with chronic alcohol intoxication were registered 48 h and 3 months after ethanol withdrawal. The changes in dopamine receptors characterized by the increased number of the sites of binding with ligand (Bmax) were most pronounced 48 h after ethanol withdrawal. In 3 months the properties of these receptors tended toward recovery. The changes in GABA receptors also manifested by the increase in Bmax become further pronounced 3 months after ethanol withdrawal.