Reduction of antibiotic treatment of bacterial meningitis in children. Value of C-reactive protein monitoring
Astruc, J.; Taillebois, L.; Rodière, M.; Peskine, F.
Archives Francaises de Pediatrie 47(9): 637-640
1990
ISSN/ISBN: 0003-9764 PMID: 2078122 Document Number: 362350
The duration of antibiotic treatment of bacterial meningitis is always a topical issue. In our study (58 children), 21 of 24 meningococcal meningitis were treated for 4 or 5 days, 16 of 22 Haemophilus influenzae and 4 of 6 pneumococcal meningitis were treated for 7 days without increase in neurologic sequelae. A return of blood CRP levels to normal values was observed in all these patients simultaneously. Thus, CRP seems to be a good biological parameter for discussing treatment discontinuation. Furthermore, in some complications such as subdural effusion, a new increase of CRP levels was observed after the 5th day. A sequential follow-up of CRP levels at days J0, 5, 7, 10, seems a very useful tool for management of bacterial meningitis.