The prognosis of the outcome and the correction of the treatment in bacterial meningitis by using immunological monitoring
Lutsik, B.D.; Kit, I.E.; Tokarev, V.P.
Terapevticheskii Arkhiv 62(11): 19-22
1990
ISSN/ISBN: 0040-3660 PMID: 2094982 Document Number: 357042
The clinico-etiological characteristics of bacterial meningitides and cellular immunity were studied over time. Measurements were made of the phagocytic index, the phagocytic number, phagocytosis completeness, E-RFC, complementary activity of blood serum (CABS), circulating immune complexes (CIC) and IgA, IgM and IgG. The low phagocytic activity of neutrophils, phagocytosis incompleteness, the high level of CIC, a considerable reduction on CABS were associated with a grave clinical course of bacterial meningitides. In fact, they served as indicators of the necessity of instituting intensive care (hemoperfusion, plasmapheresis, ultraviolet and laser blood radiation, the use of immunomodulators). The combined administration of sodium nucleinate, levamisole and hemodez provided rapid and efficient recovery of the characteristics under study.