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Toxicity of cis-platinum loaded with lactic acid oligomer microspheres in mice

Sasabe, T.; Takahashi, T.; Hagiwara, A.; Iwamoto, A.; Shimotsuma, M.; Yoneyama, C.; Itoh, M.; Hyon, S.H.; Ikeda, Y.; Kusanoi, Y.

Gan no Rinsho. Japan Journal of Cancer Clinics 36(7): 821-823

1990

ISSN/ISBN: 0021-4949
PMID: 2355467
Document Number: 362158
We have evaluated the acute toxicity of an experimental new dosage form administered intraperitoneally in mice, consisting of cis-platinum loaded with lactic acid oligomer microspheres (CDDP-ms). The LD50 value of the CDDP-ms was 23.8 mg/kg, which amounted to 176% of the LD50 of the cis-platinum solution (13.5 mg/kg). Autopsy findings revealed no additional toxicity due to this dosage form.

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