Subacute toxicity of adsorbed 250 Lf tetanus toxoid in rats
Sethi, N.; Singh, R.K.; Srivastava, R.K.
Indian Journal of Experimental Biology 28(3): 218-220
1990
ISSN/ISBN: 0019-5189 PMID: 2365417 Document Number: 361854
Since the naturally acquired tetanus antitoxin titre in Indian population is mostly less than protective levels, to minimise the incidence of morbidity, Glaxo Laboratories (India) Ltd, Bombay have prepared a single dose potent tetanus vaccine of 250 Lf as compared to 5 Lf previous tetanus toxoid. Subacute toxicity study revealed that this toxoid (250 Lf) injected at different dose levels (1-2 ml/rat/injection .times. 4) is non-toxic to rats.
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