Clinical study of the efficacy and tolerability of nimesulide in suppositories compared to flurbiprofen in gynecology
Montoneri, C.; Garofalo, A.; Iurato, S.; Scaricabarozzi, I.; Trezzani, R.
Minerva Ginecologica 42(10): 413-419
1990
ISSN/ISBN: 0026-4784 PMID: 2290600 Document Number: 361365
The efficacy and tolerability of nimesulide in a new pharmaceutical suppository form were assessed in a double blind study versus flurbiprofen in pain-inflammatory pathologies of obstetrico-gynecological nature. One hundred patients with pelvic inflammatory disease were randomly assigned to treatment with nimesulide or flurbiprofen. Both drugs, administered in a dose of 2 suppositories a day for 7 days, evidenced speedy, effective analgesic and anti-inflammatory activity combined with good tolerability. Specifically, as regards the pain component, nimesulide demonstrated a significantly more marked analgesic effect than flurbiprofen in the first two hours of treatment.