Memory deficits following internal capsule lesions in rats and their improvement by L-6-ketopiperidine-2-carbonyl-L-leucyl-L-proline amide (RGH-2202) , a thyrotropin-releasing hormone analogue
Oka, M.; Ito, T.; Furukawa, K.; Karasawa, T.; Kadokawa, T.
Archives Internationales de Pharmacodynamie et de Therapie 306: 18-33
1990
ISSN/ISBN: 0003-9780 PMID: 1981674 Document Number: 360843
The effect of purified protein kinase C (PKC) on dopamine D2 receptor binding was studied. Saturation binding with [3H]spiperone was not affected. In competition experiments using agonists PKC-treated membranes showed a significant reduction in the proportion of high affinity sites, and the influence of GTP gamma S was abolished. These results suggest that PKC-dependent mechanisms can regulate the coupling between the dopamine D2 receptor and its G-protein.