Effect of the intraventricular administration of gonadotropin-releasing hormone analogue on immune response and unspecific resistance in rats
Bobyntsev, I.I.; Sever'ianova, L.A.; Smakhtin, M.I.; Ktiukov, A.A.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 91(10): 1176-1181
2005
ISSN/ISBN: 0869-8139 PMID: 16335425 Document Number: 585861
Intraventricular administration of the synthetic analogue of gonadotropin-releasing hormone (surfagon) results in increased humoral immune response and neutrophile activation including phagocytic and special functional indices in rats. Since testosterone blood level is not changed it may be concluded that the surfagon effect is mediated by nervous mechanisms. The conclusion is also confirmed by the obtained data of the brain stress-limiting system activation manifested by the decrease of oxidative stress.