Simultaneous occurrence of calcification and amyloid deposit in pilomatricoma
Sano, Y.; Mihara, M.; Miyamoto, T.; Shimao, S.
Acta Dermato-Venereologica 70(3): 256-259
1990
ISSN/ISBN: 0001-5555 PMID: 1972845 Document Number: 360737
Amyloid deposition was encountered in 10 of 16 samples of pilomatricoma, indicating that the deposition of amyloid is nearly as common as calcification in pilomatricoma. In addition, a simultaneous occurrence of calcification and amyloid deposit in pilomatricoma was recognized in 9 of 16 samples. The calcification and the deposition of amyloid developed topographically in the same area within the shadow cell masses. Such an area was revealed as moderately basophilic, amorphous, or hyalinized by H and E staining. Electron microscopy revealed spotty calcium deposits in amyloid. No light chains of human immunoglobulin were detected in the amyloid-deposited area. Amyloid in this tumour may facilitate calcification or serve as a matrix for subsequent calcification.