Histological study of oogenesis pathology in smoky mutant mice
Ignat'eva, E.L.; Malashenko, A.M.; Blandova, Z.K.
Biulleten' Eksperimental'noi Biologii i Meditsiny 109(5): 460-462
1990
ISSN/ISBN: 0365-9615 PMID: 2378956 Document Number: 360466
The various pathology of female mice reproductive system with the mutation smoky (smk) was observed. This recessive autosomal gene dilutes the black colour of hair to the light smoky. The cases with ovarian agenesis and dysgenesis of the mutants WR-smk/smk and B6-smk/smk without the germ cells or with the acute deficit was discovered. The oogenesis pathology of the mutants B6-smk/smk was revealed by the block of oocyte growth and their nucleus development in the growing nonatretic follicles leading to the female infertility. Endogene causes of the female gypogonadism and infertility associated with the mutation smoky are proposed.