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Phosphodiesterase inhibitors

Sarkis, A.; Pornin, M.

Annales de Cardiologie et d'Angeiologie 39(7): 427-431

1990

ISSN/ISBN: 0003-3928
PMID: 2264708
Document Number: 360399
Phosphodiesterase III inhibitors constitute a new therapeutic group for congestive cardiac failure. They inhibit the degradation of cyclic adenosine monophosphate and increase the intracellular calcium. They have a double inotropic and vasodilator haemodynamics occurs without any increase in the myocardial effect. The improvement in the consumption of oxygen. The beneficial haemodynamic effect seems to last over a medium period of time, but the survival in the long term treatment is not yet known.

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