Significance of flumazenil in acute benzodiazepine poisoning
Del Busto Prado, F.; Alvarez García, A.; Ibarra Peláez, A.; Menéndez Fernándéz, J.; Barraca de Ramos, R.; Alonso Calo, L.
Medicina Clinica 94(16): 616-618
1990
ISSN/ISBN: 0025-7753 PMID: 1974312 Document Number: 360259
Thirty-five patients over 14 years of age were evaluated, with the common feature of benzodiazepine poisoning, either as a single drug or associated with others and/or with ethanol, and who had a Glasgow score lower than 10 at admission. These patients were treated with flumazenil as a competitive antagonist drug. The results were very satisfactory. Subsequently, the possible relationship between the effect of flumazenil and the pharmacokinetic benzodiazepine profile was evaluated, and a significant relationship between the half life and the degree of resedation of the patients was found.