Correction with formate of metabolic disorders in alcoholic intoxication
Gulyĭ, M.F.; Stogniĭ, N.A.; Silonova, N.V.; Shevtsova, N.F.; Solodova, E.V.
Ukrainskii Biokhimicheskii Zhurnal 62(3): 107-111
1990
ISSN/ISBN: 0201-8470 PMID: 2396317 Document Number: 360145
Formate was studied for its effect on the content of acetaldehyde, activity of the total aldehyde dehydrogenase, content of substrates of glycolysis and tricarbonic-cycle and pool of free amino acids of rat tissues during alcohol intoxication. The introduction of formate during the acute alcohol intoxication lowers the acetaldehyde content in the blood; the ethanol load being prolonged--it increases the activity of aldehyde dehydrogenase and normalizes the content of pyruvate, glutamate and malate in the liver and glutamate and oxaloacetate in the brain, that evidences for the correction of metabolic disturbances in the organism.