Problems with long-term immunosuppression following organ transplantation
Thiel, G.; Landmann, J.; Mihatsch, M.
Therapeutische Umschau. Revue Therapeutique 47(2): 138-146
1990
ISSN/ISBN: 0040-5930 PMID: 2180103 Document Number: 359091
Long-term immunosuppression is followed by an increase of malignancies (skin cancer, lymphomas and Kaposi's sarkoma). Among the infectious complications an incidence of bacteraemia up to 48% is found, a relative increase of infection with listeria and salmonella, and viruses from the herpes group. The major side effect of azathioprine is haematologic, whereas Cyclosporin A is nephrotoxic. Three classes of renal functional impairment by Cyclosporine are defined: 1. renal dysfunction, 2. acute nephrotoxicity and 3. chronic nephrotoxicity. Appropriate ways to handle chronic nephrotoxicity are discussed.