A prospective study in high risk subjects of electrocardiographic changes with ivermectin
Dukuly, Z.D.; Pacqué, M.; Nara, A.; Taylor, H.R.; Williams, P.N.; Greene, B.M.
Tropical Medicine and Parasitology Official Organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit 41(1): 73-74
1990
ISSN/ISBN: 0177-2392 PMID: 2339252 Document Number: 358535
Thirty-two elderly Liberian men, mean age 61 years, were treated with ivermectin and serial electrocardiograms (EKG's) were performed. Twenty of the 32 (62.5%) had baseline EKG abnormalities including poor R wave progression, 1 degrees AV block, non-specific intraventricular conduction abnormalities, left anterior hemiblock, supraventricular premature beats, left axis deviation, and early repolarization. Twelve lead EKG's were done twice daily, pretreatment and on five occasions post-treatment. No significant changes and no new abnormalities were observed. This study fails to demonstrate any significant cardiac effect of ivermectin.