Two additional cases of t dic(9:12) in acute lymphocytic leukemia (ALL): prognosis in ALL with dic(9:12)

Huret, J.L.; Heerema, N.A.; Brizard, A.; Provisor, A.J.; Benz-Lemoine, E.; Guilhot, F.; Savage, J.R.; Tanzer, J.; Huret, J.L; Heerema, N.A; Brizard, A; Provisor, A.J; Benz-Lemoine, E; Guilhot, F; Savage, J.R; Tanzer, J

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Two additional cases of t dic (9:12) in acute lymphocytic leukemia (ALL) : prognosis in ALL with dic (9:12)

Huret, J.L.; Heerema, N.A.; Brizard, A.; Provisor, A.J.; Benz-Lemoine, E.; Guilhot, F.; Savage, J.R.; Tanzer, J.

Leukemia 4(6): 423-425

1990

ISSN/ISBN: 0887-6924

PMID: 2193203

Document Number: 358363

We report two occurrences of dic(9;12) in acute lymphoblastic leukemia and review previous cases. Cases of dic(9;12) share common features with cases of 9p and 12p rearrangements, but prognosis seems particularly good in cases of dic(9;12). The persistence of a specific dicentric in stable clones is remarkable and points to unusual centromeric behavior and/or marked selective advantage of the anomaly.