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Antithyroid antibody dynamics in patients with Hashimoto's goiter receiving conservative treatment and after surgical interventions

Okeanova, T.A.; Vnotchenko, S.L.; Fedoseeva, G.I.; Bazarova, E.N.; Kriukova, I.V.; Konnova, E.V.

Terapevticheskii Arkhiv 62(9): 87-91

1990

ISSN/ISBN: 0040-3660
PMID: 2281417
Document Number: 358062
The content of antithyroid antibodies (AtAb) in the blood of patients with Hashimoto's goiter was studied over time, namely during the treatment with thyroid drugs and after surgical interventions of different scope. The patients' groups with diverse changes in the AtAb titers during the conservative treatment were revealed. The analogous types of the time-course of changes in antibodies to thyroglobulins (AbTg) were discovered after a surgical intervention irrespective of the operation scope whereas the persistence of antibodies to microsomal antigen (AbMa) after the operation depended on the mass of the remaining thyroid tissue. A correlation was found between the high titers of AbTg (rather than AbMa) and the elevated content of thyrotropic hormone in untreated patients with Hashimoto's goiter and after large-scope surgical interventions.

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