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Synthesis of nucleic acids and dynamics of morphological indices of the granulation tissue of skin wounds in rats treated with 4-methyluracil

Silaeva, S.A.; Khatsernova, B.I.; Golenchenko, V.A.; Berchenko, G.N.; Nikolaev, A.I.; Shekhter, A.B.

Voprosy Meditsinskoi Khimii 36(1): 82-84

1990

ISSN/ISBN: 0042-8809
PMID: 1693022
Document Number: 357591
Effect of 4-methyl uracil on dynamics of morphological patterns and the rate of nucleic acids synthesis was studied in granulation tissue developed during healing of full-layer skin wounds. Application of ointment containing 4-methyl uracil onto the wounds exhibited an antiinflammatory efficiency and decreased accumulation of leukocytes in the wound. The drug shortened the mitotic cycle in dividing fibroblasts, as a result of which periods of DNA synthesis became more frequent exhibiting two days duration. The rate of RNA synthesis was increased 1.5-2-fold. Content of acid glycosaminoglycans and collagen was increased in intercellular space surrounding fibroblasts.

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