Exudative enteropathy and interstitial cystitis due to systemic lupus erythematosus
Marteau, P.; Grange, J.D.; Michel, C.; Mosnier, J.F.; Islam, S.; Najman, A.; Mignon, F.; Bodin, F.
Gastroenterologie Clinique et Biologique 14(10): 771-775
1990
ISSN/ISBN: 0399-8320 PMID: 2262125 Document Number: 357337
A 33-year-old woman presented with chronic diarrhea, vomiting and anasarca due to systemic lupus erythematosus with protein-losing enteropathy, interstitial cystitis and glomerulonephritis. Methylprednisolone could not prevent aggravation of diarrhea, obstructive uropathy, and nephrotic syndrome, and prolonged intestinal ileus developed. Because of this steroid-resistance, bolus injections of cyclophosphamide (1 g i.v. monthly) were decided. Protein-losing enteropathy and ileus both disappeared rapidly following the first injection. Protein-losing enteropathy, intestinal ileus and interstitial cystitis are exceptional manifestations of systemic lupus erythematosus; steroid-resistance of the digestive manifestations has only been reported in one case and our observation is the first reporting the efficacy of cyclophosphamide.