Gonadotropic function of the hypophysis in girls with delayed puberty
Levenets, S.A.; Plekhova, E.I.; Cherevatova, S.K.
Akusherstvo i Ginekologiia 4: 18-21
1990
ISSN/ISBN: 0300-9092 PMID: 2116091 Document Number: 355915
Radioimmune assay of serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in 216 girls aged 13-18 years with pubertal delay (PD) unrelated to gonadal dysgenesis have shown that LH and FSH levels were normal in 48.1%; one or both gonadotropins were decreased in 17.1%, only LH level was increased in 13.9% and only FSH level in 12.6%. Hypergonadotropinemia was seen in 8.3% of the patients. Bioassay of total gonadotropin excretion was performed in 117 patients. Comparison of the radioimmune and biological assays suggested misproduction of the biologically active gonadotropins in a proportion of girls with PD. Hypoestrogenism in normogonadotropic PD appears to be related to regional blood and lymph flow disturbance.