Doxium 500 in chronic venous insufficiency: a double-blind placebo controlled multicentre study
Widmer, L.; Biland, L.; Barras, J.P.
International Angiology a Journal of the International Union of Angiology 9(2): 105-110
1990
ISSN/ISBN: 0392-9590 PMID: 2254672 Document Number: 355618
The aim of this double-blind placebo-controlled study was to evaluate the therapeutic efficacy of Doxium in chronic venous insufficiency (CVI). 225 patients were treated randomly for 4 weeks with 1.5 g (3 capsules/day) of Doxium or placebo. The evolution of the leg oedema was determined by measuring calf and ankle circumferences. Pain and discomfort were assessed by visual analogue scale. The results show that at the end of the trial, all the examined parameters (leg oedema, pain, day and night cramps, discomfort, heavy legs, paresthesia and restless legs) were significantly more improved in the Doxium group than in the placebo group: the leg volume was diminished by 3.8% in the Doxium group compared to 1.2% in the placebo (p < 0.005). The overall assessment by the physicians an improvement in 82% of the Doxium-treated patients compared to 42% of the placebo group (p < 0.0001). The tolerance of the treatment was comparable in both groups.