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Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by western blot and radioimmune assay

Weinshenker, B.G.; Dekaban, G.; Rice, G.P.

Neurology 40(8): 1251-1253

1990

ISSN/ISBN: 0028-3878
PMID: 2381534
Document Number: 354968
We were unable to identify an antibody to either HTLV-I or HIV-1 in patients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.

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