Binding affinity of ibuprofen to collagen and other connective tissue components
Menzel, E.J.; Kolarz, G.
Arzneimittel-Forschung 40(4): 481-483
1990
ISSN/ISBN: 0004-4172 PMID: 2357251 Document Number: 354860
In vitro binding of ibuprofen to various tissue components was studied to explain differences in tissue concentration after local application of ibuprofen cream (Dolgit Creme). Radioactive ibuprofen was incubated with human Collagen Type I to V, Elastine, bovine, Mouse-Laminin, and Matrigel of the mouse, respectively. In low concentrations.sbd.similar to plasma concentrations after percutaneous application of ibuprofen.sbd.a specific binding especially to Laminin and Collagen Type IV could be found. This finding possibly explains previous autoradiographic results, which showed higher concentrations of ibuprofen in connective tissue compared with fat and other surrounding tissues.