Effectiveness of TRH analog in a case of early infantile epileptic encephalopathy
Ishii, M.; Tamai, K.; Sugita, K.; Tanabe, Y.
No to Hattatsu 22(5): 507-511
1990
ISSN/ISBN: 0029-0831 PMID: 2121173 Document Number: 353910
We reported a case of early infantile epileptic encephalopathy (EIEE) due to perinatal hypoxic-ischemic brain damage. This infant had frequent brief tonic seizures in series accompanied by apnea and bradycardia since two days after birth. Her EEG showed a typical suppression burst pattern. We administered PB. VPA and CZP, but could not control her seizures at all. Then, a thyrotropin releasing hormone (TRH) analog, in addition to PB and VPA, was administered intravenously (0.5 mg/day) to her. Three weeks after the administration of this TRH analog, her seizures ceased completely. We suggest that TRH analog therapy should be considered as one of therapeutics for EIEE whose prognosis is expected to be poor.