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Single drug chemotherapy with 5-FU oral administration of bladder cancer

Ueno, M.; Yoshikawa, H.; Hasegawa, K.; Sasaki, H.; Onodera, Y.; Ikeuchi, T.; Kai, Y.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 17(10): 2109-2111

1990

ISSN/ISBN: 0385-0684
PMID: 2221933
Document Number: 353677
58-year-old male with bladder cancer complicated acute myocardial infarction (aMI) were treated by 5-FU 300 mg/day orally for approximately one and a half months as single drug chemotherapy preoperatively. CT studies showed PR in bladder lesion and an improvement of bilateral hydronephrosis also. Biochemical evaluations as Thymidylate synthase inhibition and FdUMP were made on biopsy and operative specimens of urinary bladder. Clinical trials with 5-FU oral administration in bladder cancer were not held widely. Although its effectiveness and safety has been accepted in several fields. It was useful for a conservative operation case as single drug chemotherapy.

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