Effects of acute hypoxia on the development of corazol-induced seizures

Agadzhanian, N.A.; Torshin, V.I.; Shevchenko, L.V.; Elfimov, A.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 109(6): 529-531

1990


ISSN/ISBN: 0365-9615
PMID: 2397286
Document Number: 353312
Experiments on white random-bred rats showed that development of corazol seizures depend both on corazol dose and pO2 level n atmosphere. Latent period becomes short, the time of convulsive attack and the time of all seizures prolongs with increase of corazol dose. Acute hypoxia inhibits development of seizures: decreases the time of attack and the time of all seizures, prolongs latent period. The higher the hypoxia level is more massive its protective effect on corazol seizures. The anticonvulsant mechanisms of acute hypoxia are under discussion.

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