Natriuretic and antihypertensive effects of acute hypoxia in animals with spontaneous hereditary hypertension
Meerson, F.Z.; Barbarash, N.A.; Dvurechenskaia, G.I.; Prokina, N.S.; Saltykova, V.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 90(8): 142-144
1980
ISSN/ISBN: 0365-9615 PMID: 7407383 Document Number: 156215
The influence of acute hypoxia in a high-pressure chamber on renal secretion of sodium and water, as well as the influence of prolonged altitude hypoxia in the mountains (2100 m high) on arterial pressure were studied in spontaneously hypertensive rats (SHR) and Wistar rats. It was established that the diuretic and natriuretic effect of acute hypoxia in SHR was twice as high as that in control. Accordingly, even during the first three days of the exposure to prolonged altitude hypoxia the arterial blood pressure in SHR decreased fromn 196 to 158 mm Hg. In control animals, the arterial pressure remained unchanged. It is postulated that the diuretic and natriuretic effects underlie the mechanism of the antihypertensive action in both acute hypoxia and during adaptation to it.