Prognostic relevance of histopathologic subtyping of nodular-sclerotic types of Hodgkin's disease
Adamkov, M.; Plank, L.
Bratislavske Lekarske Listy 91(6): 433-436
1990
ISSN/ISBN: 0006-9248 PMID: 2393825 Document Number: 351855
The paper analyzes the histopathologic pattern of 30 bioptically assessed cases of nodular-sclerotic (NS) type of Hodgkin's disease diagnosed before onset of therapy. The ratio of lymphocytes and tumor cells, as well signs of atypia, pleomorphism and blastic proliferation of tumor cells were evaluated in each case. On the basis of this analysis, the NS type was divided into the subtype NS 1 (14 cases) and subtype NS 2 (16 cases). In the subtype NS 1 lymphocytes were predominant in the tumor nodes and there were only few Sternberg-Reed cells, which were either isolated or in small clusters. Fibrosis in the tumor nodes was mild. In the subtype NS 2 the ratio of lymphocytes was lower, Sternberg-Reed cells were numerous and were found to be in groups and clusters. Pleomorphism and atypia of the tumor cells was remarkable. Pronounced fibrosis was seen in the nodes. The ratio of reactive cells and necroses exhibited individual variation in both subtypes. Statistical evaluation of survival time showed significant differences between the patients with subtype NS 1 and NS 2. Differentiation between NS 1 and NS 2 subtypes of the nodular-sclerotic type of Hodgkin's disease can thus ben considered to be prognostically relevant.