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Prediction of water vapor transport rates across polyvinylchloride packaging systems using a novel radiotracer method

Wood, R.W.; Mulski, M.J.; Kuu, W.Y.

Journal of Parenteral Science and Technology a Publication of the Parenteral Drug Association 44(5): 278-281

1990

ISSN/ISBN: 0279-7976
PMID: 2250204
Document Number: 351644
A radiotracer method is used to study the transport properties of water vapor in polyvinylchloride (PVC), a plastic commonly used in the packaging of parenteral solutions. Water vapor transport across a PVC film appears to be Fickian in nature. Using the steady-state solution of Fick's second law and the permeability coefficient of water vapor across the PVC film obtained using the described method, the predicted water vapor transport rate (WVTR) for a parenteral solution packaged in PVC is in reasonable agreement with actual WVTR as determined by weight loss under precisely controlled conditions.

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