A method for evaluating the effectiveness of preservative systems in water-immiscible ointments
Abshire, R.L.; Schlech, B.A.
Journal of Parenteral Science and Technology a Publication of the Parenteral Drug Association 36(5): 216-221
1982
ISSN/ISBN: 0279-7976 PMID: 6765553 Document Number: 190258
A procedure designed specifically for determining the effectiveness of antimicrobial preservatives in an ophthalmic ointment was evaluated. Except for Staphylococcus aureus, the USP XX battery of challenge microorganisms worked well in the system. This procedure can be used to challenge preserved ointments and determine if such preparations meet the same test requirements as those set forth in the compendium for preserved solutions and suspensions. Other laboratories should study this method so that its usefulness for evaluating the effectiveness of preservatives in ointments can be defined.