Clinical experience in Mexico with a new oral rehydration solution with lower osmolality
Velásquez-Jones, L.; Becerra, F.C.; Faure, A.; de León, M.; Moreno, H.; Maulén, I.; Abraham-Jalil, A.; Muraira, A.
Clinical Therapeutics 12(Suppl): 95-103
1990
ISSN/ISBN: 0149-2918 PMID: 2340539 Document Number: 350744
A clinical trial was conducted to compare safety and efficacy of a new oral rehydration solution (ORS) with that of the ORS recommended by the WHO with 130 infants with dehydration due to acute diarrhoea: 68 infants received the WHO ORS containing sodium 90 and glucose 111 mmol/litre and an osmolality of 311 mosm/kg (ORS-90); 62 infants received an 0RS with Na 60 and glucose 90 mmol/litre, with an osmolality of 240 mosm/kg (ORS-60). Treatment failure was noted in 7 infants in the ORS-90 group; causes of failure were high stool output (3 cases) persistent vomiting (3 cases) and ileus (1 case). Only 1 patient in the ORS-60 group (1.6%) was considered a failure because of high stool output. No significant differences were noted in serum Na in either group both in relation to the natraemia seen on admittance or that seen after rehydration. A trend was observed toward correction of hypernatraemia or hyponatraemia with both types of ORS. A similar situation was observed with respect to the variations in serum potassium.