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Spectral-fluorescent characteristics of rat transcortin in normal conditions and during experimental circulatory insufficiency

Nadol'nik, L.I.; Chaĭkovskaia, N.A.; Beluga, V.B.; Vinogradov, V.V.

Ukrainskii Biokhimicheskii Zhurnal 62(4): 77-80

1990

ISSN/ISBN: 0201-8470
PMID: 2238157
Document Number: 349655
Spectral-fluorescent parameters of rat transcortin isolated from blood plasma of intact rats and rats with circulatory insufficiency were studied. The differences in the Schtern Folmer constants and the dissociation constants for the transcortin-corticosterone complex obtained during the protein titration by corticosterone may be due to different tryptophanyl surroundings in the molecules of the studied proteins. This may be a consequence of the conformational rearrangements of the corticosteroid-binding globulin molecules.

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