Characterization of the elastase 1-simian virus 40 T-antigen mouse model of pancreatic carcinoma: effects of sex and diet
Longnecker, D.S.; Kuhlmann, E.T.; Freeman, D.H.
Cancer Research 50(23): 7552-7554
1990
ISSN/ISBN: 0008-5472 PMID: 2174728 Document Number: 349535
Elastase 1-simian virus transgenic mice were studied to characterize the development of pancreatic neoplasms. The incidence of pancreatic carcinomas was compared in groups of male and female mice fed 1 of 3 diets: stock diet; diet containing 5% maize oil and 20% casein; or diet containing 20% maize oil and 20% casein. Male mice developed more exocrine carcinomas than female mice and their tumours were larger. Groups fed on the stock diet had fewer exocrine carcinomas than groups fed purified diets. Including 5 or 20% maize oil did not alter tumour incidence. An unexpectedly high incidence of islet cell tumours was found in all dietary groups, with a higher incidence in females than in males.