Stability of conjugative and non-conjugative R-plasmids from Serratia marcescens to gyrase inhibitors
Llanes, C.; Michel-Briand, Y.; Thouverez, M.; Bailly, C.; Grimont, F.
Microbiologica 13(2): 157-159
1990
ISSN/ISBN: 0391-5352 PMID: 2161994 Document Number: 348680
The stability of conjugative and non-conjugative R-plasmids was compared using two gyrase inhibitors (novobiocin and ciprofloxacin). Conjugative R-plasmids from eighteen ticarcillin resistant Serratia marcescens were more stable than non-conjugative R-plasmids from eleven ticarcillin resistant bacteria of the same species. Moreover, novobiocin (gyrase B sub-unit inhibitor) is a better curing agent than ciprofloxacin (A sub-unit inhibitor).