Oral trapidil treatment of Fontaine stage Ii arteriosclerotic circulatory disorders of the legs--a double-blind study
Voigt, H.; Reuter, W.; Hofmann, B.; Dobberkau, A.
Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 45(10): 283-287
1990
ISSN/ISBN: 0044-2542 PMID: 2392858 Document Number: 348182
In a double blind study altogether 41 patients with obliterating arteriosclerosis at stage II after Fontaine have been treated for 26 weeks either with 3 X 100 mg Trapidil (Rocornal) daily or placebo. In the second half of the study under Trapidil in contrast to placebo a clinically relevant additional increase of the distance of the intermitent claudication was the result. On the other hand, the plethysmographically measured reserve of the arterial blood supply did not show any changes in the two groups. A specific influence of Trapidil on the lipoprotein metabolism is apparently not present, since there appeared favourable influence on the hyperlipoproteinaemia diagnosed in 37 out of 41 patients both under placebo and under Trapidil.