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Drug-protein interactions. Comparative studies of levamisole and structural analogs or agents with immunomodulatory effect on the mechanism of protein aggregation

Chicault, M.; Luu-Duc, C.; Boucherle, A.

Arzneimittel-Forschung 40(1): 55-57

1990

ISSN/ISBN: 0004-4172
PMID: 2340000
Document Number: 348040
Interactions of tetramisole, imidazo[2,1-b]thiazolic derived or immunomodulatory agents with human serum albumin (HSA) and immunoglobulins G and A has been investigated in vitro using polyacrylamide gel electrophoresis and immunoelectrophoresis. The results suggest that only the chemical structure type of tetramisole is able to induce a protein-protein interaction described as a mechanism of disulfide-sulfhydryl interchange reactions. The groups of atoms involved in the interaction are characterized.

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Chicault, M.; Luu Duc, C.; Boucherle, A. 1982: Drug -- protein interactions in vitro. Effect of levamisole on human serum albumin Arzneimittel-Forschung 32(4): 393-398
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