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Drug-protein interactions. a study of levamisole-serum albumin complex by 1H-NMR spectroscopy

Chicault, M.; Luu-Duc, C.; Boucherle, A.; Nardin, R.

Arzneimittel-Forschung 38(9): 1369-1372

1988

ISSN/ISBN: 0004-4172
PMID: 3223978
Document Number: 312961
The chemical interaction of levamisole with human serum albumin (HSA) has been investigated using the technique of nuclear magnetic resonance spectroscopy. Binding to HSA occurs primarily with the imidazolidine and thiazolidine groups of levamisole as it has been demonstrated by selective changes in the relaxation times and the chemical shifts of the protons attached to the carbon atoms. The complex appears as the result of a weak linkage and may play a primordial role in the protein-protein interaction.

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