Epidemiological and immunological features of tetanus under conditions of long-term planned vaccine prophylaxis
Gil', I.V.; Sokhin, A.A.; Sliusar', L.I.; Vereshchagina, V.I.; Radomskaia, F.S.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 6: 38-43
1989
ISSN/ISBN: 0372-9311 PMID: 2800792 Document Number: 347350
The introduction of mass immunization against tetanus has resulted in the decrease of morbidity rate (5.2 times), the leveling of morbidity rate among the urban and rural population and among males and females, though no essential effect on the seasonal distribution of tetanus morbidity has been observed. Persons over 50 years of age (housewives and pensioners) have become the main groups of risk at the post-immunization period. Mass immunization against tetanus over a period of many years has ensured the existence of a sufficient immune stratum (89.9 +/- 3.0% to 100 +/- 3.0%) and a sufficient level of antitoxic immunity (means geom equal to 6.72-9.6 I.U./ml) among children. Among adults, the proportion of persons protected from tetanus decreases in older age groups from 82.1 +/- 1.3% in persons aged 31-40 years to 22.1 +/- 2.0% in persons over 60 years. The observed differences between the coverage of the population with immunization and the proportion of persons having protective titers of tetanus antibodies require constant control of the intensity of immunity and its correction with regard to its initial level, especially in persons of older age groups.