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Detection of latent spontaneous pathology of the central nervous system and visceral organs in rabbits by determining antibodies to tissue antigens and by a test for delayed hypersensitivity

Kulikova, O.S.; Magaeva, S.V.; Martynenko, A.V.; Martynenko, M.V.

Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 5: 47-49

1989

ISSN/ISBN: 0031-2991
PMID: 2616216
Document Number: 347129
Complex immunological, pathologicoanatomic and histopathological examination of intact rabbits revealed a correlation between the appearance of complement fixation antibodies and delayed hypersensitivity to tissue antigens on the one hand and the development of spontaneous pathology of the corresponding organs on the other. Meningoencephalitis was diagnosed in all sick animals by means of immunological tests. Tests for antibodies and delayed hypersensitivity to tissue antigens revealed intracapillary glomerulonephritis, coccidiosis of the liver, and pneumonia. The authors recommend conduction of immunological tests for detecting latent spontaneous pathology in laboratory animals.

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