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Domperidone, an inhibitor of the D2-receptor, blocks a late phase of an electrically induced long-term potentiation in the CA1-region in rats

Frey, U.; Hartmann, S.; Matthies, H.

Biomedica Biochimica Acta 48(7): 473-476

1989

ISSN/ISBN: 0232-766X
PMID: 2803284
Document Number: 346690
The influence of the D2-receptor blocker domperidone (DP) at a concentration of 1 .mu.M was investigated on an electrically induced long-term potentiation (LTP) measured as the enhancement of the population spike (PS) amplitude in the hippocampal CA1. It could be shown that the drug does not influence the initiation but the maintenance of LTP. The results once again support the hypothesis the different phases of LTP exist which are realized by different cellular inputs.

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