Tissue-type plasminogen activator--biochemistry, physiology and clinical use
Gmiński, J.; Flak, A.
Wiadomosci Lekarskie 42(19-21): 1055-1059
1989
ISSN/ISBN: 0043-5147 PMID: 2517807 Document Number: 346450
Tissue plasminogen activator (t-PA) is the main physiological activator of the fibrinolysis process present in nearly all organs, tissues and secretions. Its most important function is dissolving of intervascular fibrin deposits. T-PA is synthesized and secreted by the endothelium of blood vessels in response to various stimuli. Its enzymatic activity in plasma is controlled by rapidly acting inhibitors. Reduced generation of t-PA activity may be the cause of thrombotic changes in the vascular system. Studies are conducted presently on the use of t-PA in thrombolytic treatment.