Homologous cerebral atrophy and ischemic insults in progeria adultorum
Haustein, J.; Pawlas, U.; Cervós-Navarro, J.
Zentralblatt für Allgemeine Pathologie U. Pathologische Anatomie 135(1): 51-56
1989
ISSN/ISBN: 0044-4030 PMID: 2929184 Document Number: 346060
Neuropathological findings obtained from a female patient, 49 years of age, with progeria adultorum (Werner's syndrome) are described in this paper. Vascular sclerosis with multiple ischaemic infarctions, cerebral atrophy, and vascular myelopathy were the most strongly pronounced CNS findings. Also recorded were severe lipofuscin depositions from the cortex, dentate nucleus, and olivae as well as amylaceous bodies in the insula of Reil and the hippocampus. Neurofibrillary tangles or plaques were not recordable. The central nervous system proved somewhat comparable to other organs, in that mesenchymal regressive changes were the main features.