LiCl and CCK inhibit gastric emptying and feeding and stimulate OT secretion in rats
McCann, M.J.; Verbalis, J.G.; Stricker, E.M.
American Journal of Physiology 256(2 Pt 2): R463-R468
1989
ISSN/ISBN: 0002-9513 PMID: 2537039 Document Number: 345883
Systemic injection of the nauseogenic agent lithium chloride increases neurohypophyseal secretion of oxytocin (OT) in rats. The induced OT secretion was related exponentially to the inhibition of food intake. A similar relation between OT secretion and food intake also was observed after systemic injection of cholecystokinin (CCK). The effects of each agent on food intake lasted much longer than the observed increases in OT secretion. LiCl and CCK produced a dose-dependent inhibition of gastric emptying in rats that was closely related temporally to the inhibition of food intake. The similarity of these 3 responses to LiCl and CCK suggests that both agents stimulate common central mechanisms, apparently involving magnocellular and parvocellular neurons in the paraventricular nucleus of the hypothalamus, whereby these neuroendocrine, behavioural and autonomic functions are integrated.