Suppression of human monocyte interleukin 1 production by the plant alkaloid tetrandrine
Seow, W.K.; Ferrante, A.; Li, S.Y.; Thong, Y.H.
Clinical and Experimental Immunology 75(1): 47-51
1989
ISSN/ISBN: 0009-9104 PMID: 2539275 Document Number: 345847
The bisbenzylisoquinoline alkaloid, tetrandrine, was shown to affect some important human monocyte functions. The drug caused significant inhibition of random movement, chemotaxis, superoxide anion generation and interleukin 1 (IL-1) production. By contrast, degranulation and hexose-monophosphate shunt activity were unaffected. Tetrandrine may be of value in the treatment of chronic inflammatory diseases where IL-1 has a major role as an inflammatory mediator.
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