Intermediate filaments. Efficacy in surgical pathologic diagnosis
Nagle, R.B.
American Journal of Clinical Pathology 91(4 Suppl 1: S14-S18
1989
ISSN/ISBN: 0002-9173 PMID: 2467554 Document Number: 345460
The use of antibodies specific for the various types of intermediate filament proteins has become an important part of the immunohistochemical approach to surgical pathology. These proteins are expressed in a cell lineage-specific pattern, which is reproduced with great fidelity even in poorly differentiated neoplasms. The historic discovery, embryology, and structure of these proteins are reviewed. A brief discussion of the major applications and precautions in the choice and use of these antibodies is presented.