Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effect of long-term nifedipine treatment on body fluid composition in essential hypertension

Toftdahl, D.B.; Andersen, G.S.

Journal of Human Hypertension 3(3): 203-206

1989

ISSN/ISBN: 0950-9240
PMID: 2769676
Document Number: 344646
The antihypertensive efficacy and effects on body fluid composition of monotherapy with the calcium antagonist nifedipine were investigated in 15 patients with essential hypertension. The systolic as well as the diastolic blood pressure decreased significantly, by approximately 12%, during nifedipine treatment with a mean dose of 56 mg. Glomerular filtration rate, plasma volume, extracellular fluid volume, and the ratio plasma to interstitial fluid volume did not change significantly. The most frequently observed side-effects were flushing and peripheral oedema which occurred in four and three patients, respectively. These results indicate that sodium and water retention, which is often observed during long-term treatment with vasodilators, does not seem to be the explanation of the development of peripheral oedema seen with nifedipine.

Document emailed within 1 workday
Secure & encrypted payments

Khosseĭn, A.; Mukharliamov, N.M.; Mareev, V.I.; Lobova, N.M.; Ageev, F.T. 1988: Long-term use of the calcium antagonist nifedipine (corinfar) in the treatment of patients with primary pulmonary hypertension Kardiologiia 28(4): 54-58
Okrucká, A.; Pechán, J.; Kratochvílová, H. 1995: Effect of long-term celiprolol therapy on haemostasis in essential hypertension Journal of Human Hypertension 9(9): 773-776
Wnuk, R.; Kokot, F. 1991: Effect of nifedipine treatment on the renin-aldosterone system and secretion of cortisol and growth hormone in patients with essential hypertension Endokrynologia Polska 42(3): 421-427
Syvertsen, J.O.; Bratland, B.; Dahlöf, B.; Gisholt, K.; Os, I.; Tretli, S. 1992: Treatment with lisinopril or nifedipine in essential hypertension. a Norwegian multicenter study of the effect, tolerance and quality of life of 828 patients Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin Ny Raekke 112(27): 3432-3436
Milei, J.; Lemus, J.; Bernardiner, E. 1986: Ketanserin in the treatment of essential hypertension. a double-blind study against metoprolol and a further long-term open treatment Acta Cardiologica 41(6): 427-441
Bouchard, C.; Tremblay, A.; Nadeau, A.; Dussault, J.; Després, J.P.; Theriault, G.; Lupien, P.J.; Serresse, O.; Boulay, M.R.; Fournier, G. 1990: Long-term exercise training with constant energy intake. 1: Effect on body composition and selected metabolic variables International Journal of Obesity 14(1): 57-73
Leth, A. 1970: Changes in plasma and extracellular volume during long-term hydrochlorthiazide treatment of patients with essential hypertension Nordisk Medicin 84(33): 1042-1046
Giuntoli, F.; Guidi, G.; Galeone, F.; Rossi, A.; Giacomelli, A.; Saba, P. 1985: Efficacy of captopril in the long-term treatment of essential hypertension of moderate-medium degree La Clinica Terapeutica 115(4): 261-265
Hosie, J.; Nasar, M.A.; Belgrave, G.P.; Walters, E.G. 1994: A comparative study of long acting diltiazem (Tildiem LA) with sustained release nifedipine (nifedipine SR) and bendrofluazide in the treatment of mild to moderate hypertension Acta Cardiologica 49(3): 251-265
Dodson, P.M.; Pacy, P.J.; Cox, E.V. 1985: Long-term follow-up of the treatment of essential hypertension with a high-fibre, low-fat and low-sodium dietary regimen Human Nutrition. Clinical Nutrition 39(3): 213-220
Rasić-Milutinović, Z.; Perunicić, G.; Pljesa, S.; Gluvić, Z.; Ilić, M.; Stokić, E. 2007: The effect of nutritional status, body composition, inflammation and serum iron on the developement of insulin resistance among patients on long-term hemodialysis Medicinski Pregled 60(Suppl 2): 33-38
Paris, J.V.; González, C.A. 1991: Nicardipine and nifedipine in the treatment of essential arterial hypertension Proceedings of the Western Pharmacology Society 34: 303-309
Dubuc, P.U.; Peterson, C.M. 1990: Ineffectiveness of parenteral fluoxetine or RU-486 to alter long-term food intake, body weight or body composition of genetically obese mice Journal of Pharmacology and Experimental Therapeutics 255(3): 976-979
Portaluppi, F.; degli Uberti, E.; Strozzi, C.; Margutti, A.; Montanari, L.; Rambaldi, R.; Trasforini, G.; Pansini, R. 1987: Slow-release nifedipine: effect on the circadian rhythm of blood pressure in essential hypertension Acta Cardiologica 42(1): 37-47
Bragulat, E.; Larrousse, M.; Coca, A.; de la Sierra, A. 2003: Effect of long-term irbesartan treatment on endothelium-dependent vasodilation in essential hypertensive patients British Journal of Biomedical Science 60(4): 191-196
Trovato, G.M.; Iannetti, E.; Murgo, A.M.; Carpinteri, G.; Catalano, D. 1998: Body composition and long-term levo-carnitine supplementation La Clinica Terapeutica 149(3): 209-214
Brunner, H.R.; Waeber, B.; Nussberger, J.; Schaller, M.D.; Gomez, H.J. 1983: Long-term clinical experience with enalapril in essential hypertension Journal of Hypertension. Supplement: Official Journal of the International Society of Hypertension 1(1): 103-107
Aoki, K.; Sato, K. 1982: Acute hypotensive, hemodynamic effects of long-term treatment with niludipine, a Ca2+-antagonist, in patients with essential hypertension. Niludipine monotherapy and combination with a beta-blocker and a diuretic) Arzneimittel-Forschung 32(9): 1141-1145
Mitrovic, V.; Patyna, W.; von Bruchhausen, V.; Schlepper, M. 1991: Nifedipine-clonidine combination in essential hypertension. Hemodynamic and neurohumoral findings of the combination in comparison with the effect of the individual substances Fortschritte der Medizin 109(32): 663-666
Widimský, J.; Horký, K.; Gregorová, I.; Dvoráková, J. 1987: Essential hypertension with low and high renin levels. Comparison of the results of long-term therapy Casopis Lekaru Ceskych 126(19): 582-585