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Cytomegalovirus retinitis treated with ganciclovir in a renal transplant recipient

Horng, I.H.; Chen, M.S.; Lee, P.H.; Chen, Y.C.; Lee, C.S.; Hou, P.K.

Journal of the Formosan Medical Association 88(11-12): 1152-1155

1989

ISSN/ISBN: 0371-7682
PMID: 2561486
Document Number: 343653
Cytomegalovirus retinitis is an opportunistic and vision-threatening disease in immunosuppressed patients. Currently available antiviral agents have been unsuccessful in halting its progression. We report a case of cytomegalovirus retinitis which occurred 6 months after renal transplantation and was successfully treated with an investigational drug, ganciclovir (DHPG [Dihydroxy propoxymethyl guanine], Cytovene, BW-B759U), via intravenous administration, with resolution of active retinal lesions and the cessation of cytomegalovirus shedding in the urine. There was neither a recurrence of cytomegalovirus retinitis nor an occurrence of retinal detachment during the 9-month follow-up after intravenous ganciclovir therapy.

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