Opioid peptides. Partially modified retro-inverso dermorphin analogues. XIIi
Marastoni, M.; Balboni, G.; Tomatis, R.; Salvadori, S.; Borea, P.A.; Uccelli, L.
Farmaco 44(11): 1083-1093
1989
ISSN/ISBN: 0014-827X PMID: 2562001 Document Number: 343528
We studied the effect of partial retro-inverso modification of a selected peptide bond of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) related peptides. The drastic loss of mu-receptor affinity following introduction of retro-inverso peptide bond between Phe1-D-Ala2 in the new peptide analogues, emphasized the importance of this backbone in the dermorphin peptides.