Modulation of excitation transfer in the intracardiac ganglionic system by the opioid peptide dermorphin
Sokolova, N.A.; Deĭgin, V.I.; Iarova, E.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 105(4): 438-439
1988
ISSN/ISBN: 0365-9615 PMID: 2896024 Document Number: 318051
The aim of the study was to determine whether opioid peptides could modulate the intracardiac ganglionic excitation. It has been shown that postganglionic impulse activity recorded in the frog intracardiac nerve was inhibited by endogenous amphibian opioid peptide-dermorphin (10(-12)-10(-6) M). The inhibition was blocked by naloxone (10(-5) M). Dermorphin (10(-6) M) had no influence on transitory impulse activity in the intracardiac postganglionic sympathetic fibers. It is suggested that opioid peptides take part in the mediatory process in the intracardiac ganglia.